Antithrombotische Therapie und Prophylaxe in Schwangerschaft und Puerperium

Chronische Virushepatitis - Naturgeschichte, Diagnostik und Therapie

Rivaroxaban - Ein neuer, oraler, direkter Faktor-Xa-Inhibitor in der klinischen Entwicklung zur Prophylaxe und Therapie thromboembolischer Erkrankungen

Rivaroxaban (Xarelto®) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Rivaroxaban inhibits clot-associated and free FXa activity, and prothrombinase activity, and reduces thrombin generation. In animal models, rivaroxaban prevented venous and arterial thrombosis, and was effective at treating venous thro...

Management von Hypophysen- und Nebennierenerkrankungen in der Schwangerschaft

Management of Pituitary and Adrenal Disorders in Pregnancy. Pregnancy in concomitant pituitary or adrenal disorders requires special medical attention and treatment since maternal and fetal morbidity and mortality may be increased. If previously known and adequately treated, pregnancy in Addison’s disease can take an inconspicuous course. However, it is associated with an increased rate of prem...

Akutes Koronarsyndrom Peri-interventionelle antithrombotische Therapie

Zusammenfassung Bei Patienten mit akutem Koronarsyndrom erlangte die peri-interventionelle antithrombotische Therapie in den vergangenen Jahren zunehmend Bedeutung für die Wahl der bevorzugten Reperfusionsstrategie und der adjuvanten medikamentösen Behandlung vor, während und nach perkutanen Koronarinterventionen (PCI). Bei NSTE-ACS und früh-invasiver Therapiestrategie (<48 h) sollte möglichst ...

Direkte Ethanolmetabolite in Blut und Urin: Relevanz in Diagnose und Therapie alkoholbezogener Störungen

Direct Ethanol Metabolites. Currently available biological state markers of alcohol intake are limited in two basic respects: (1) Their time spectra are limited to only recent intake (e.g. serum ethanol detects only use within the past several hours) or long-term, chronic intake through measurement of adverse consequences of heavy drinking on end-organ functioning (gamma glutamyl transpeptidase...